Genome-wide gene-environment analyses of depression and reported lifetime traumatic experiences in UK Biobank

Genome-wide gene-environment analyses of depression and reported lifetime traumatic experiences in UK Biobank

全基因组的，基因环境分析，抑郁症和已经报道的终身创伤经历，UKBB

Depression is more frequently observed among individuals exposed to traumatic events. The relationship between trauma exposure and depression, including the role of genetic variation, is complex and poorly understood. The UK Biobank concurrently assessed depression and reported trauma exposure in 126,522 genotyped individuals of European ancestry. We compared the shared aetiology of depression and a range of phenotypes, contrasting individuals reporting trauma exposure with those who did not (final sample size range: 24,094- 92,957). Depression was heritable in participants reporting trauma exposure and in unexposed individuals, and the genetic correlation between the groups was substantial and not significantly different from 1. Genetic correlations between depression and psychiatric traits were strong regardless of reported trauma exposure, whereas genetic correlations between depression and body mass index (and related phenotypes) were observed only in trauma exposed individuals. The narrower range of genetic correlations in trauma unexposed depression and the lack of correlation with BMI echoes earlier ideas of endogenous depression.

抑郁症是遗传与环境综合作用的结果，创伤经历。我们的研究兴趣是这两者之间的关系，UKBB最近有很多数据。我们比较了抑郁症的共同病因和一系列表型，有无创伤经历。

抑郁症是可遗传的，遗传相关性是显著的，接近于1. （怎么算的？）抑郁症与精神病性状之间的遗传相关性都很强（什么意思？）

而抑郁症与体重指数（及相关表型）之间的遗传相关性仅在创伤暴露个体中观察到。(为什么在无创伤经历的人中观察不到？)

没有经历创伤的抑郁症的遗传相关性范围较窄，缺乏与BMI的相关性说明了早期的内源性抑郁症的观点。（什么叫endogenous？）

待续~