生命组学-药物基因组学 精准医学的内容有个人全基因组测序,移动可穿戴设备,它可以实时监测,深度学习模型预测疾病,对疾病预测做到有效.安全和可控. 药物基因组学就是研究疾病.化合物和靶点之间的关系,关键是找到能控制疾病的蛋白质结合腔. 遗传性疾病可通过家系研究,非遗传性疾病可通过GWS找突变位点,基于突变情况找治疗方法.SBI是结构生物学与药物分子设计与生信相结合的学科. 药物制造的传统问题是不知道潜在的药物靶标,针对某一症状而不是疾病,广泛测试得到小分子,最后再调整基团,效率极低. 现代的药物基…

生物信息学 Cell theory:7个要点 All known living things are made up of one or more cells. All living cells arise from pre-existing cells by division. The cell is the fundamental unit of structure and function in all living organisms. The activity of an organi…

10X Genomics已经广泛应用于单细胞测序.组装领域,现在也是火的不行. 10X Genomics原理 通过将来自相同DNA片段(10-100kb)的reads加上相同的barcode,然后在illumina平台上进行测序,从而实现长片段的测序.其基本原理是同一长片段的reads会具有同样的标签,称为linked-reads,利用这些barcode的信息,可将短reads拼接为长reads.这样的linked-reads可进行结构变异检测及单倍型定相的分析. 总结:10X Genomics…

In the model layer, the Model class is the base class while the ModelBase class is metaclass.…

单细胞流程跑了不少,但依旧看不懂结果,是该好好补补了. 有些人可能会误会,觉得单细胞的RNA-seq数据很好分析,跟分析常规的RNA-seq应该没什么区别.今天的这篇文章2015年3月发表在Nature Genetics Review上,专门说明了一下单细胞RNA测序数据在数据分析和计算上的挑战(虽然已经过去1年多了,这里指出的问题和挑战仍然是不过时的,至于这些问题和挑战现在是不是完美解决了,这里就暂且先不讨论了.). 主要说了以下问题: 1. 单细胞RNA测序 (single cell RNA…

Transcriptional benchmarking of in vitro cells to in vivo with single-cell rna-seq - 简介 Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types - 原文 目前发育生物学的实验基础有两类, 一是活体小鼠,作为模式动物:为了把小鼠上的研究造福于人类(诊断.筛查.药物开发…

A Complete Tutorial on Tree Based Modeling from Scratch (in R & Python) MACHINE LEARNING PYTHON R   SHARE      MANISH SARASWAT, APRIL 12, 2016 / 52     Introduction Tree based learning algorithms are considered to be one of the best and mostly used s…

Systems and methods are provided to manage risk associated with access to information within a given organization. The overall risk tolerance for the organization is determined and allocated among a plurality of subjects within the organization. Allo…

http://www.doppioslash.com/ https://github.com/Apress/physically-based-shader-dev-for-unity-2017 Part I: Introduction to Shaders In Unity Chapter 1: How Shader Development Works (已看) Chapter 2: Your First Unity Shader (已看) Chapter 3: The Graphics Pip…

Character level language model - Dinosaurus land Welcome to Dinosaurus Island! 65 million years ago, dinosaurs existed, and in this assignment they are back. You are in charge of a special task. Leading biology researchers are creating new breeds of…